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In Vitro Activity of Doripenem against Pseudomonas aeruginosa and Burkholderia cepacia Isolates from both Cystic Fibrosis and Non-Cystic Fibrosis Patients

机译:多瑞培南对囊性纤维化和非囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌分离株的体外活性

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摘要

The in vitro activities of doripenem, imipenem, levofloxacin, piperacillin, ceftazidime, aztreonam, tobramycin, and cefepime were determined for 160 isolates of Pseudomonas aeruginosa (82 from cystic fibrosis [CF] patients) and 34 isolates of Burkholderia cepacia. Doripenem MIC90s were lower than those of all other comparative agents against all isolates combined and against all P. aeruginosa isolates. Doripenem was as active as levofloxacin and 2- to 32-fold more active than the other comparative agents against B. cepacia.
机译:测定了160株铜绿假单胞菌(来自囊性纤维化[CF]患者的82株)和34株洋葱伯克霍尔德菌的多利培南,亚胺培南,左氧氟沙星,哌拉西林,头孢他啶,氨曲南,妥布霉素和头孢吡肟的体外活性。对于所有合并的分离物和所有铜绿假单胞菌分离物,多瑞培南MIC90均低于所有其他比较剂。多瑞培南的活性与左氧氟沙星同等,并且比其他抗洋葱败血病的比较剂高2至32倍。

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